Interestingly, LH and E2 levels, which were inversely associated with tumor size, were moderately positively linearly correlated with only the lumbar of age-matched BMD parameters (Z scores) (Figure 1, Figures S6 and S7, Tables S5 and S6), which were consistent with the previously demonstrated protective roles of LH and E2 on bone fracture [21]. The gene discussed is PLOD1; the disease is neoplasm.