The maximum ACTH-secreting pituitary adenoma diameter was positively correlated with the blood ACTH levels and both serum and urinary cortisol (Figure 1 and Figure S3, Table S2), and inversely linearly correlated with all ten age-matched BMD parameters (Z scores), thus larger tumor size was associated with lower BMD Z scores (Figure 1 and Figure S3, Table S2). Here, POMC is linked to pituitary gland adenoma.