BCL2 and neoplasm: BCL2 was considered positive when the BCL2 protein was expressed in more than 70% of the tumor cells.7 Lymphoma cells were assigned a germinal center B-cell-like (GCB) or non-GCB phenotype using the Hans algorithm for cell-of-origin subtyping.12 A fluorescence in situ hybridization analysis was performed on formalin-fixed, paraffin-embedded tissue sections.