In contrast, the top canonical pathways significantly changed in Atp8b1 mutant as a result of aging are OX40 signaling, altered T cell and B cell signaling in rheumatoid arthritis, communication between innate and adaptive immune cells, the antigen presentation pathway, agranulocyte adhesion, and diapedesis (Table 3). This evidence concerns the gene TNFRSF4 and rheumatoid arthritis.