Interestingly, blood vessels in angiogenic brain metastases of the human melanoma cell line Mel57-VEGF165 [41] were homogeneously positive (see representative example in Figure 2C) while staining was absent in Mel57-VEGF165 tumors after treatment with the VEGFR2 inhibitor vandetanib [42] (Figure 2D). Here, KDR is linked to melanoma.