Bearing in mind findings herein from two independent TMAs that expression of TPα and TPβ isoforms are significantly but differentially altered as a function of both PCa staging and progression (time to disease-free/BCR-free survival), we sought to investigate whether altered CpG methylation of the TBXA2R gene might play a role in the transcriptional regulation of TPα and TPβ, potentially accounting for the observed differences in TPα and TPβ expression in PCa. This evidence concerns the gene BCR and posterior cortical atrophy.