Furthermore, global genomic DNA demethylation with 5-Aza-2′-deoxycytidine (5-Aza-dC) led to significant increases in both TPα (2.8 -fold) and TPβ (4.5-fold) mRNA expression, and of the control GST-π mRNA-amplicon, in the adenocarcinoma LNCaP and PC-3 cell lines (Figure 4B), confirming that the TBXA2R gene may be regulated by CpG methylation. The gene discussed is PLAT; the disease is adenocarcinoma.