While a recent study revealed that the tumour suppressors Wilms' tumour (WT) 1 and hypermethylated in cancer (HIC)1 transcriptionally regulate TPα expression through binding to cis-elements within Prm1 in both prostate and breast cancer cell lines [57], to the best of our knowledge no study has yet investigated the mechanisms governing the transcriptional regulation of TPβ through Prm3 in similar settings. The gene discussed is PLAT; the disease is breast carcinoma.