Indeed, in the specific context of PCa, activation of the PRKs (e.g. PRK1) in response to androgen receptor (AR) signalling catalyses phosphorylation of histone (H)3 at Thr11 (H3pThr11) which, in-turn, serves as a specific epigenetic marker and gatekeeper of androgen induced-chromatin remodelling and -gene expression within the prostate [19, 32–34]. The gene discussed is PKN1; the disease is posterior cortical atrophy.