RHOA and cancer: Increased levels of TXA2 and expression of its synthase and its T prostanoid receptor, the TP, have been found in a number of prevalent cancers [8] and, mechanistically, the role of TXA2 in cancer may be explained by the ability of the TXA2-TP axis to regulate key mitogenic/extracellular signal regulated kinase (ERK)- and RhoA-mediated signalling cascades that contribute to tumour development and metastasis [9, 10].