PLAT and adenocarcinoma: Consistent with previous findings in megakaryocytes [26, 27], Prm1 and Prm3 were confirmed to exclusively regulate TPα and TPβ expression, respectively, in the human prostate tissue and adenocarcinoma cell lines as evidenced by the finding that the 5′-most nucleotide (TI site) of TPα mRNA mapped to exon/E1 while the 5′-most nucleotide of TPβ mRNA mapped to its TI site at nucleotide −12 located within exon/E2 (Figure 4C and 4D).