In more recent studies, it was also discovered that both TPα and TPβ directly interact with and regulate signalling by protein kinase C-related kinase/protein kinase novel (PRK/PKN) [19], a family of 3 AGC kinases and RhoA effectors that act immediately downstream of phosphatidyl inositol (Pi) 3′kinases and strongly, yet differentially, implicated in several cancers [29–31]. Here, RHOA is linked to cancer.