PLAT and cancer: Bearing in mind the mounting evidence for the role of the TXA2 –TP axis in cancer progression but also of the clear functional and regulatory differences between the TPα and TPβ isoforms [10, 18–23], it was deemed imperative to investigate expression of the individual TPα and TPβ isoforms in PCa and to establish whether cytoplasmic expression of either isoform within the glandular epithelium might correlate with Gleason grade.