Added to this complexity, the TPα and TPβ isoforms appear to differentially associate with- and regulate-signalling by the individual PRKs (PRK1/PKNα, PRK2/PKNγ, PRK3/PKNβ), suggesting clear functional differences between TPα and TPβ within the prostate and, potentially, in PCa [35]. This evidence concerns the gene PKN1 and posterior cortical atrophy.