Hence, the discovery that the TXA2-TP signalling axis can directly activate the PRKs to induce the essential chromatin modifications (H3pThr11) necessary to support AR-mediated gene expression within the prostate even in the absence of androgens per se led us to interrogate the role of TXA2 in PCa, including in CRPC [19, 35]. This evidence concerns the gene AR and posterior cortical atrophy.