While a recent study revealed that the tumour suppressors Wilms' tumour (WT) 1 and hypermethylated in cancer (HIC)1 transcriptionally regulate TPα expression through binding to cis-elements within Prm1 in both prostate and breast cancer cell lines [57], to the best of our knowledge no study has yet investigated the mechanisms governing the transcriptional regulation of TPβ through Prm3 in similar settings. This evidence concerns the gene PRM1 and breast cancer.