Collectively, these data show highly significant differences in the CpG methylation status of Prm1 and Prm3 of the TBXA2R in both the benign/BPH tissue and also during the transition and progression of PCa, whereby the changes that occur in PCa begin at the HGPIN stage and result in a nett increased methylation of Prm1 and a nett decreased methylation of Prm3, potentially accounting for the variable expression of TPα in PCa and the more global increase in TPβ expression as a function of Gleason grade. Here, PRM3 is linked to posterior cortical atrophy.