PLAT and posterior cortical atrophy: Bearing in mind findings herein from two independent TMAs that expression of TPα and TPβ isoforms are significantly but differentially altered as a function of both PCa staging and progression (time to disease-free/BCR-free survival), we sought to investigate whether altered CpG methylation of the TBXA2R gene might play a role in the transcriptional regulation of TPα and TPβ, potentially accounting for the observed differences in TPα and TPβ expression in PCa.