Furthermore, and in the context of PCa, TPα and TPβ differentially regulate signalling by the PRKs, a RhoA effector known to act as a specific gate-keeper of androgen receptor (AR) -mediated chromatin remodelling (H3pThr11) and hence, androgen-dependent gene expression within the prostate [19, 32–34]. This evidence concerns the gene RHOA and posterior cortical atrophy.