Specifically, and consistent with the higher level of TPα mRNA expression in the prostate and clonal cell lines, it was found that Prm1 is hypomethylated in benign tissues and precursor lesions but that it undergoes increased methylation across primary and metastatic PCa stages potentially accounting for the overall reduced level of TPα such as generally observed across the “Malmö TMA”. The gene discussed is PLAT; the disease is posterior cortical atrophy.