Furthermore, while two-way contingency analyses (Fisher exact) showed that there was no significant difference in TPα expression between benign/BPH and a combined Gleason 3/4/5 cohort, there was a marginal, but significant nett decrease noted between benign/BPH and Gleason 3 groupings (P = 0.0458; Table 1A). This evidence concerns the gene PLAT and benign prostatic hyperplasia.