In addition to miR-15a/16-1 cluster, a lncRNA, DLEU2 was found co-deleted in the minimally deleted region (DMR) of del(13q14), hence implicating a potential tumor suppressor role of DLEU2. Interestingly, downregulation of DLEU2 in CLL has recently been ascribed to DNA methylation of its CpG islands [22]. This evidence concerns the gene DLEU2 and B-cell chronic lymphocytic leukemia.