CASP9 and neoplasm: Moreover, treatment with Z-LEHD-FMK, a caspase 9 inhibitor, rescued the percentage of dead cells by 9% in BM742401-overexpressing cells (P = 0.012, Supplementary Figure S3), but not in cells with empty vector, confirming the tumor suppressive role of BM742401 is mediated by the intrinsic, Caspase-9 dependent apoptotic pathway.