In CLL cell lines, M-/U-MSP analysis showed that the promoter of BM742401 was completely methylated (MM) in MEC1, I83-E95 and WAC3CD5+, partially methylated (MU) in HG3, and completely unmethylated (UU) in MEC2, 232B4, and CLL-AAT (Figure 1C). The gene discussed is SERPINA1; the disease is B-cell chronic lymphocytic leukemia.