Thirdly, BM742401 gene exists in an antisense orientation to a neighboring protein-coding gene GATA6. Moreover, in CLL cell lines, methylation-mediated silencing of BM742401 was linked to a lower expression of its neighboring protein-coding gene, GATA6. GATA6 is implicated in human cancers as TSGs or oncogenes. The gene discussed is GATA6; the disease is B-cell chronic lymphocytic leukemia.