Importantly, in a mouse model with cre-mediated excision of exon 4 of TRIM24 (TRIM24dlE4/dlE4), Khetchoumian K et al found that deficiency of TRIM24 may lead to continuous hepatocytes proliferation, spontaneous hepatocarcino-genesis, and increased susceptibility to chemically induced HCC [15, 16, 27]. Here, TRIM24 is linked to hepatocellular carcinoma.