The number of Ki67-immunoreactive tumor cell nuclei, indicating mitotic cells, was considerably increased in a focally accentuated fashion in all tumors irrespective of the genotype whereas mitotic activity was low in the non-neoplastic liver parenchyma (Figure 3I), although in areas with morphologic features of SH Ki67-positive hepatocytes were more frequent than in those with less conspicuous alterations (Figure 4C). This evidence concerns the gene MKI67 and neoplasm.