IGFBP3 and hepatocellular carcinoma: Many known human HCC-associated oncogenes were upregulated in Krt18−/− liver tumors [bcl11a, ccnd3 [14], igfbp3 [15], npm [16], rab27b [17], srebf1 [18], stat3 [19], wnt3 [20]] and known human HCC tumor suppressor genes were down-regulated [rab11a [17], runx3 [21]] (Figure 7).