However, the number of animals with fatty liver as well as the steatosis grades increased with age and keratin deficiency status: in 17-20-months-old mice only mild steatosis was found in about one third of wt mice whereas it was mild to moderate in almost all Krt18+/− and Krt18−/− mice (Figure 2D). The gene discussed is KRT18; the disease is hyperinsulinemic hypoglycemia, familial, 4.