TP53 and colorectal carcinoma: These CRC cell lines represent both pathways of CRC carcinogenesis (microsatellite vs. chromosomal instability) [36, 37], differ in their genetic profile, e.g in TP53 status (wild type vs. mutated) [37] which contributes to the regulation of cellular metabolism and radioresponse [38], and supposedly vary in their sensitivity to arginine deprivation in monolayer culture (resistant vs. sensitive cell line) [18].