Given that both the activation of MYC and loss of the PTEN tumor suppressor are frequently observed in PCa, and when these abnormalities are combined in mouse models they drive genome instability and metastasis of PCa [60], it will be important to carefully evaluate the functions of miR-22 in PCa in the context of its upstream regulatory signals and downstream target genes. The gene discussed is MYC; the disease is posterior cortical atrophy.