KMT5A and fetal growth restriction: Since canonical Wnt/β-catenin signaling is activated by SETD8- catalyzed H4k20me1 which is decreased in hippocampus, the authors hypothesized that reduced PPARγ-SETD8-H4K20me1 and Wnt signaling may contribute to altered hippocampal cellular composition which, in turn, may contribute to impaired neurodevelopment and subsequent neurocognitive impairment in IUGR offspring [76].