A single-nucleotide polymorphism (SNP), namely polymorphism rs16917496 T>C, which is located within the binding site of another miRNA, miR-502, in SETD8 3′UTR, modulates SETD8 protein expression, and thus contributes to susceptibility to breast and ovarian cancer, and clinical outcome of small cell lung cancer and hepatocellular carcinoma [63–66]. This evidence concerns the gene KMT5A and hepatocellular carcinoma.