As recently demonstrated by Hamamoto and coworkers, SETD8 is overexpressed in different types of cancer tissues and cancer cell lines including bladder cancer, non-small cell and small cell lung carcinoma, chronic myelogenous leukemia, hepatocellular carcinoma and pancreatic cancer [28]. The gene discussed is KMT5A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.