ICAM1 and brain ischemia: Data showed that pretreatment with sodium β-aescin for 7 d could remarkably alleviate cerebral ischemia/reperfusion injury induced by MCAO, resulting from significantly reducing the cerebral infarct volume and ameliorating the neurological deficits through downregulating the protein expressions of ICAM-1 and E-selectin and inhibiting the migration of neutrophils after cerebral ischemia/reperfusion [20].