Accordingly, we examined whether (1) the development of nicotine plus AngII-induced AAA in the mouse is accompanied by altered local production of MCP-1 and RANTES under control of the JNK pathway in vivo and (2) exposure of cultured MOVAS cells to nicotine has an effect on their cellular chemokine expression, which may induce the migration of RAW264.7 cells. The gene discussed is MAPK8; the disease is triple-A syndrome.