An increase in autophagosomes in the center of fibers in which mitochondria are actively being degraded may imply greater mitophagy; however, the LC3 plaque evident in some fibers in which mitochondria were clearly absent may indicate impaired fusion with the lysosome and incomplete recycling as is evident in other diseases, such as sporadic inclusion-body myositis [49]. This evidence concerns the gene MAP1LC3A and inclusion body myositis.