Exploring the individual genes, several of them were related to morbidity in TS e.g. aortic aneurysm (ZFYVE9), obesity (CNR1), melanocytic nevi (DOCK7)49, and the insulin-like-growth factor system (IGFBP3), which is known to be perturbed in TS50. The gene discussed is IGFBP3; the disease is aortic aneurysm.