Although ADR is known to require CARP-1 for apoptosis signaling in breast cancer including TNBC cells [4, 6], and ADR-resistant TNBC cells express elevated levels of CARP-1, CFM-4.16 exposure caused a further increase in CARP-1 levels in ADR-resistant cells (Figure 3). This evidence concerns the gene CCAR1 and breast cancer.