TP53 and non-small cell lung carcinoma: Because mutation of the p53 gene is one of the most significant molecular events occurring in about 50% of NSCLC and plays important roles in the tumorigenesis of lung epithelial cells and resistance to clinical treatments [13], we also included IHC for p53 in this study and the positive immunostainings of mutant p53 was detected in 312 (69.2%) cases.