Neurodegenerative tauopathies, a group of diseases including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Pick’s disease, are characterized by the presence of inclusions within neurons comprised of the microtubule (MT)-binding protein, tau [4, 25, 33]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.