TRPV4 and cancer: Given that TRPV4 was shown to be expressed in the esophagus and colon epithelium, and that we recently showed that TRPV4 is expressed in mouse and rat gastric epithelia 12 and is suppressed in several cancers, we examined TRPV4 mRNA expression in human gastric biopsy samples as well as AGS cells.10, 15, 17TRPV4 mRNA was detected in HP (‐) normal human gastric biopsy samples, but not in AGS cells (Figure 1A) or in several other gastric cancer cell lines (eg, MKN28, MKN45, data not shown).