Recent studies revealed that TRPV4 function is affected by gain‐ or loss‐of‐function mutations, membrane trafficking, or gain of channel function itself.7, 13, 14, 15, 16 In addition, TRPV4 expression is downregulated in some cancers by an unknown mechanism.17, 18 However, epigenetic modulations of TRPV4 expression have not been reported. Here, TRPV4 is linked to cancer.