As recent studies suggested that H. pylori infection induced methylation silencing in gastric epithelium and gastric cancer cells,4, 5 we examined the effect of the demethylating agent 5‐azacytidine (5‐Aza, 10 μM) or 5‐AzaDC (1 μM) on TRPV4 mRNA expression in AGS cells and found that TRPV4 expression could be recovered with both demethylating agents (Figure 2A,B). Here, TRPV4 is linked to gastric cancer.