TRPV4 and gastric cancer: Based on recent studies suggesting that H. pylori infection induces methylation silencing in gastric epithelium and gastric cancer cells,4, 5 together with the presence of CpG islands in human TRPV4 (Figure 3A) and our result showing that demethylating agents could recover functional TRPV4 expression in AGS cells (Figures 1 and 2), we hypothesized that TRPV4 expression in human gastric epithelial cells can be suppressed by DNA methylation.