SIX1 and open-angle glaucoma: Given the complexity and genetic mutational heterogeneity of POAG recent GWASs have identified a number of polymorphisms in multiple loci/genes including caveolin (CAV1/CAV2) [12], atonal homolog 7 (ATOH7) [13], sin oculis homeobox (SIX1/SIX6) [14], cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) [6, 14] and TMCO1 [6, 14] that may contribute to the development and/or progression of POAG in various ethnic groups.