It is noteworthy to mention here that TMCO1 interacts with another known POAG susceptibility gene, CAV1 via the von Hippel-Lindau (VHL) tumor suppressor protein-containing E3 ubiquitin ligase [7, 23]; and we have previously shown that SNP rs4236601 in CAV1/CAV2 is not a risk factor for POAG in Saudi population [24], plausibly suggesting that TMCO1 may not have an important role in POAG pathogenesis in this population. Here, VHL is linked to open-angle glaucoma.