In addition, ROC analysis indicated that the diagnostic ability of CEA, Cyfra 21-1 and a combination of CEA and Cyfra 21-1 with the AUC values of 0.739~0.829 is similar to that of serum TFA panels with the AUC values of 0.735~0.760 between HC and BLDs plus LC (Table 7), while serum TFA panels have exhibited a slightly better diagnostic ability to differentiate HC plus BLDs from LC compared with serum tumor markers (Table 7). Here, CEACAM5 is linked to neoplasm.