CD274 and non-small cell lung carcinoma: Based on encouraging activity in early trials, durvalumab is currently being evaluated in several phase III trials in NSCLC such as ARCTIC, a global, phase III, randomized, open-label multicenter study (NCT02352948) which aims to asses the 1) safety and clinical activity of durvalumab versus standard of care (SoC) in patients with PD-L1+ tumors; and 2) the combination of durvalumab plus tremelimumab or either agent as monotherapy versus SoC in patients with PD-L1− tumors [111].