In breast cancer cell lines MCF10a, MCF7, and MB231, levels of MALAT1 were significantly decreased by treatment with 100 nM 17β-Estradiol (E2), and the E2 treatment affects breast tumor cells proliferation, migration and invasion in an ERα -independent, but a dose-dependent way by decreasing the MALAT-1 RNA level [42]. This evidence concerns the gene MALAT1 and breast carcinoma.