The levels of Low Density Lipoprotein receptor (LDLR), which is responsible for FenestraTM uptake (mediated by the ApoE receptor), and of VEGF which is responsible for neovascularization were comparable to the non-tumor liver in spontaneously developing tumors (p > 0.05) and significantly lower in the xenograft model (p = 0.0001 for LDLR and p = 0.015 for VEGF) (Fig. 3c). The gene discussed is VEGFA; the disease is neoplasm.