TPP1 and neoplasm: When considering tumor burden in live animals, a significant increase in tumor volume was demonstrated in the control group (from 511.4 ± 869.8 mm3 to 1450 ± 1389 mm3, p = 0.034) and in the ITPP group (96 ± 97.7 mm3 to 883 ± 934 mm3, p = 0.008).