SIRT3 and neoplasm: SIRT3 downregulation reduces tumor burden in vivo (Alhazzazi et al., 2011a); however, significant decreases in SIRT3 mRNA and protein level were due to the effect of (‐)‐epigallocatechin‐3‐gallate, an antioxidative catechin commonly found in green tea (Tao & Lambert, 2014).