Since depressive illness and stress are closely linked to cellular senescence22, 23, our findings that Wip1 deficiency either in Wip1 null mice or in CUMS-exposed mice increased cellular senescence in hippocampus, a key brain structure in the pathophysiology of depression24, 25, extend our knowledge to understand the regulatory role of Wip1 in mediating brain cellular senescence and depression. Here, PPM1D is linked to depressive symptom measurement.