In vitro and in vivo experiments using overexpression and knockdown revealed that the expression of GALNT2 suppresses IGF-1-induced cell growth, migration, and invasion of NB cells by modifying O-glycans on IGF-1R, which suppresses IGF-1-triggered IGF-1R dimerization and subsequent downstream signaling events (Table 1) [90]. The gene discussed is GALNT2; the disease is neuroblastoma.