Tumor-associated glycan changes comprise increased branching of N-glycans, higher density of O-glycans, generation of truncated versions of normal counterparts (Tn, sTn, and T antigens), and generation of unusual forms of terminal structures with sialic acid and fucose (sLea and sLex epitopes), mainly caused by the genetic and epigenetic desregulation of glycogenes and the tumor microenvironment. Here, EEF1A2 is linked to neoplasm.