IFN-γ-secreting Th1 CD4+ helper T-cells are the major mediators of type 1 diabetes,31 and the balance of Th1 and Th2 cytokines is very important for the development of type 1 diabetes.32 Therefore, we analyzed the expression of Th lineage cytokines in T cells. Here, CD4 is linked to type 1 diabetes mellitus.