A group of microRNAs that inhibit CTHRC1 were reported to block tumor growth.22, 23 Currently, factors such as demethylation of the CTHRC1 promoter and canonical Wnt signaling are known to upregulate CTHRC1.24, 25, 26 However, the regulation and function of CTHRC1 in the tumor microenvironment is largely unknown. The gene discussed is CTHRC1; the disease is neoplasm.