ANGPT2 and neoplasm: Ang-2 binds the endothelial-specific receptor tyrosine kinase Tie2 and promotes infiltration of Tie2-expressing circulating monocytes into tumor tissues, a step required for the formation of tumor blood vessels.16 On the basis of this report, we hypothesized that upregulation of Ang-2 by CTHRC1 in ECs promotes infiltration of TEMs into pancreatic cancer tissues.