ANGPT2 and neoplasm: We focused on Ang-2 expression among CTHRC1-induced proangiogenic factors because CD45+ cell infiltration into the tumor tissues is increased and because CD45+ cells of the monocytic lineage comprise the largest and most heterogeneous group of bone marrow-derived cells that function as vascular modulators.30 The majority of CD45+ cells was F4/80+ TAMs and TEMs, which express Tie2 and thus are able to respond to Ang-2.