In the network of dysregulated microRNA-mRNA/pathways, the following associations were made: 1) miR-132 could target MEIS1 and MAP7; 2) miR-193a could target WT1 and c-kit; 3) miR-744 could target HOXA3; 4) miR-152 could target MSI2; 5) miR-200c could target GATA2; 6) miR-92a and miR-660 could cause p53 down-regulation directly or indirectly in AML and lung cancer; and 7) miR-132 could promote p53 down-regulation by targeting SIRT1. These microRNA expression profiles were consistent with the observed gene-expression profiles in the network of dysregulated-mRNA/pathways. This evidence concerns the gene SIRT1 and lung cancer.