In addition to environmental factors, genetic susceptibility to RCC has been evaluated in numerous candidate-gene association studies, in which several single nucleotide polymorphisms (SNPs) from relevant biologic pathways have been associated with RCC risk1 including several genetic variants in genes that are involved in the renin-angiotensin-aldosterone system (RAAS) and hypertension pathways2, 3, 4. This evidence concerns the gene REN and renal cell adenocarcinoma.