Mutations in POU1F1 cause Combined Pituitary Hormone Deficiency (CPHD), which is typically characterized by lack of GH, TSH and PRL [30–34], while mutations in PROP1 cause progressive hormone deficiency that can include GH, TSH, PRL, gonadotropins and ACTH [29, 35–39]. This evidence concerns the gene PRL and Combined pituitary hormone deficiencies, genetic forms.