Moreover, our discordance rate is similar to, or slightly lower than, the rates published from studies using direct sequencing with surgical specimen (4.5–28.6%)[9, 11–13, 15], which also suggest the efficacy of EBUS-TBNA targeting LNs especially for EGFR testing in advanced NSCLC. This evidence concerns the gene EGFR and non-small cell lung carcinoma.