For example, admission histone levels were associated with ALT levels, INRs, sequential organ failure response syndrome (SOFA), and model for end-stage liver disease (MELD) scores in ALF patients, but weakly correlated with systemic inflammatory response syndrome (SIRS) score, serum Tbil, and serum creatinine levels (Supplementary Table 1). Here, GPT is linked to systemic inflammatory response syndrome.