HMOX1 and hereditary hemochromatosis: In fact, it is well established that chronic iron overload aggravates hepatic stellate cell activation, whereas progression to fibrosis positively correlates with exposure to iron in hereditary hemochromatosis.42, 43 Of note, our results showed that, in parallel with HO-1 overexpression, BDL RIP3−/− mice displayed improved parameters of oxidative stress and fibrosis at early time-points, together with increased hepatic siderosis.