GPT and Hyperbilirubinemia: Strikingly, upon BDL, serum levels of ALT and AST were significantly reduced in RIP3−/− mice compared with WT mice (P<0.05), at day 3 post-BDL, without any rescue for the hyperbilirubinemia and ALP elevation, indicating that the benefit of RIP3 deficiency in acute liver injury cannot be ascribed to changes in cholestasis.