HOTAIR and osteosarcoma: Thus, HOTAIR may be an important target in the treatment of human osteosarcoma.101 It has been reported that the small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin (AMOT) gene expression in human osteosarcoma cells.102 In particular, tissue samples from primary osteosarcomas (n=20) and adjacent normal tissues (n=20), as well as samples from the osteosarcoma cell lines SAOS-2, MG63, and U2OS and the human osteoblast cell line hFOB (OB3), were studied using quantitative real-time polymerase chain reaction to detect SNHG12 expression.