TUG1 and osteosarcoma: Moreover, ANCR regulated and controlled cell cycles by regulating the endogenous levels of cell cycle-related proteins, including p21, CDK2, and CDK4.108 The levels of taurine-upregulated gene 1 (TUG1) and one of its transcript variants (n377360) were significantly higher in osteosarcoma tissues compared with that in matched non-tumorous tissues.