Western blot analysis also showed that expression levels of MMP-2, MMP-9, p-ERK and p-JNK in lung adenocarcinoma tissues were increased compared with those in normal tissues (Supplementary Figure S5).The alteration patterns of these protein expressions in xenograft tumor tissues and human tissues were consistent with those protein expressions identified in vitro in miR-623-expressing cells and NC-transfected cells. This evidence concerns the gene MAPK8 and lung adenocarcinoma.