TNF and glaucoma: Glial derived TNF-α has been closely linked to the induction of neuronal apoptosis in a variety of acute and degenerative models, including following excitotoxic injury,33, 53, 54, 55 and during progression of glaucoma.34, 56, 57 To confirm the effects of WFA on secretion of TNF-α, we probed retinal sections from KA challenged and control eyes with antibodies to TNF-α to observe the effect of IF inhibition in vivo.