PLAUR and cancer: PLAUR does not possess any intracellular or transmembrane domains, however, it can induce intracellular signaling via interaction with other receptors.8 Expression of PLAUR in quiescent tissues is low, whereas its overexpression has been observed in many cancers and is associated with poor survival and prognosis.9 Over the last decades significant amount of experimental data provided evidence for multiple roles of PLAUR in cancer biology (reviewed recently in ref. 9).