In multiple reports in different cancer types, signaling through this axis has been described as a driver of tumor EMT20, 21 and given these observations, blockade of EGFR signaling has been explored and shown to revert the phenotype of tumor cells from a mesenchymal-like to an epithelial one.20, 22 Interestingly, long exposure to EGFR-TKIs, resulting in the acquisition of tumor resistance and relapse, has been linked to the acquisition of mesenchymal properties in tumor cells, as mesenchymal-like cells are less sensitive to the cytotoxic effects of EGFR inhibition.23, 24, 25, 26. The gene discussed is EGFR; the disease is cancer.