LMNA and neoplasm: The acquisition of epithelial features has been previously shown by our laboratory to favor caspase-mediated lysis of tumor cells and thus to improve cytotoxicity mediated by T cells and NK cells.18 Unlike epithelial tumor cells that can be efficiently lysed via caspase-dependent or independent mechanisms, we have previously shown that carcinoma cells undergoing EMT are poorly lysed by caspase-dependent mechanisms due to a defective nuclear lamin degradation as a result of decreased phosphorylation following apoptotic triggering.