PRF1 and neoplasm: This apoptotic defect, however, can be overcome by perforin/granzyme-mediated pathways, as granzymes have been previously shown to directly mediate the degradation of the nuclear lamins regardless of their phosphorylation status.42 Our data with short-term erlotinib further demonstrates that alleviation of mesenchymal features sensitizes tumor cells to lysis by restoring susceptibility to caspase-dependent pathways.