In previous studies, our group and others have shown that acquisition of mesenchymal traits by carcinoma cells could lead to resistance to immune-mediated cytotoxicity.17, 18, 28 Consistent with those reports, lung cancer cells with a more epithelial phenotype (H3255, HCC827) demonstrated a higher susceptibility to natural killer (NK) cells (Figure 3a) or TRAIL-mediated lysis (Figure 3b), compared with cells with a more mesenchymal phenotype (HCC4006). This evidence concerns the gene TNFSF10 and lung cancer.