However, HCC cells expressing high level of a specific antigen, such as PROM1 (CD133),5 THY1 (CD90),6 epithelial cell adhesion molecule (EpCAM)7 and CD24,8 often exhibit cancer stem-like property, attribute to tumor metastasis and result in a dismal clinical prognosis. Here, PROM1 is linked to hepatocellular carcinoma.