We show that the background corrected TB antigen stimulated levels (TBAg-Nil) of seven soluble markers (IL-1ra, IL-2, IL-13, IL-15, IFN-γ, IP-10 and macrophage chemoattractant protein 1 (MCP-1)) distinguished both the active TB and LTBI groups from the QFT negative controls. This evidence concerns the gene IL15 and tuberculosis.