Of note, Love et al (2009) demonstrated SGCd to have a 14-fold increased level of extracellular expression in BPH RNA compared with PCa RNA, whereas Savas et al (2010) identified single-nucleotide polymorphisms (SNPs) associated with SGCd and selenium resistance – a dietary trace element shown to protect against various cancers including PCa (Platz and Helzlsouer, 2001; Meuillet et al, 2004; Neill and Fleshner, 2006). Here, SGCD is linked to posterior cortical atrophy.