FOXM1 and metastatic melanoma: [23] Results of a study on melanoma showed that elevated miR-149 was found in metastatic melanoma cell which can targets glycogen synthase kinase-3α, resulting in increased expression of Mcl-1 and enhance the ability of melanoma cell to resist apoptosis, so miR-149 act as oncogene in melanoma.[24] A study on non-small cell lung cancer demonstrated that miR-149 directly targeted FOXM1 which may promote the metastasis of the tumor cell.