It has been demonstrated that syndecan-4 may play a role in collagen cross-linking, left ventricle stiffness, and cardiac fibrosis[9, 15, 16, 18], and is involved in cardiac injury and repair, including granulation tissue formation, and neorevscularization after myocardial infarction [10, 11, 14, 19, 20]. This evidence concerns the gene SDC4 and myocardial infarction.