We hypothesized that each of the three variants, rs1799883 (FABP2), rs1501299 (ADIPOQ) and rs5065 (ANP), could be related to key underlying pathological processes of MetS and, that a genetic risk score representing their cumulative effect could be a predictor of MetS-risk in Afro-Caribbeans. This evidence concerns the gene NPPA and metabolic syndrome.