Moreover, there is no effective therapy for prostate cancer with metastasis.[33] CD147, a new marker receiving attention in current research on tumors, is highly expressed in malignant tumors.[34] It can promote the invasion and metastasis of tumors by promoting the expression of MMPs.[35] Moreover, it plays an important role in protecting tumor cells that are involved in glycolysis.[36] Recent studies have found that CD147 is closely associated with multiple cancers, including gastric cancer, hepatocellular carcinoma, and ovarian cancer.[37–39]. This evidence concerns the gene BSG and hepatocellular carcinoma.