Individual differences in the production of IL-8 have been linked to a functional polymorphism (T>A at position –251) in the promoter region of IL-8 gene and the AA genotype was reported to contribute most to the expression and activity of IL-8 chemokine.[12,13] Given these findings, several lines of evidence have revealed a significant association of IL-8 gene –251T>A with altered risk of AD, however, obtained conflicting results, which may be due to the ethnicity variation and relatively small size of individual study. Here, CXCL8 is linked to Alzheimer disease.