CXCL8 and Alzheimer disease: In the current meta-analysis, we found evidence of a significant association between the IL-8 gene –251T>A polymorphism and increased risk of AD by the overall analysis with 9 case-control studies involving 1406 cases and 2152 controls, which was not in line with some individual studies, indicating that the sample size was likely significant for the assessment concerning the IL-8 gene –251T>A polymorphism and the risk of AD.