FGF19 and spindle cell hemangioma: However, recent studies demonstrated that TSH, through its receptor, triggered hepatic sterol regulatory element-binding protein (SREBP)[26] and further study revealed that the SREBP negatively regulated the transcription of FGF19 in human intestinal cells; this suggested that SREBP may act as an upper stream of FGF19 and negatively regulated the expression of FGF19.[27] The lower concentration of FGF19 in patients with OH and SCH shows that the pathways of energy metabolism are intermingled at a more fundamental level.