As shown in Fig. 2, serum FGF19 levels of patients with OH or SCH were significantly decreased, compared with the HC group (78.7 [52.7–121.2] vs 292.4 [210.2–426.5] pg/mL, P <0.001; 95.8 [71.7–126.3] vs 292.4 [210.2–426.5] pg/mL, P <0.001). The gene discussed is FGF19; the disease is spindle cell hemangioma.