AFP and cholangiocarcinoma: The shape of the former is more commonly lobulated due to the tendency to form satellite lesions when invading bile duct branches.[16] In contrast, cHCC-CC tends to form an irregular shape due to its infiltrative nature.[17] Some serologic markers, including higher serum levels of carbohydrate antigen-199 than in HCC and higher serum levels of alpha-fetoprotein (AFP) than in cholangiocarcinoma, have been described.[18]